Abstract
Results on optical clearing kinetics of rat skin ex vivo and on in vivo study of change of blood microcirculation in the rat underlying tissues with Laser Speckle Contrast Imaging (LSCI) at application of aqueous 40%-glucose solution are presented. Kinetics of weight, thickness, area and collimated transmittance of rat skin ex vivo at the wavelength range of 500-900 nm were measured. Increase of skin collimated transmittance, transverse and along skin shrinkage and weight loss was observed for the first 20-60 min of immersion. Subsequent transverse and along swelling and weight increase was observed after that. Basing on all these data, the glucose diffusion coefficient in rat skin ex vivo was calculated as (1.06±0.88)×10‒6 cm2/s. In in vivo study, we have found the change of blood microcirculation under action of 40%-glucose solution. The effect of vasodilatation expressed in the increase of microvessel size and the decrease of average rate of microcirculation were observed.
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