Abstract
We evaluated the effects of isoproterenol in right ventricular papillary muscles derived from normal and failing isolated human hearts. Basal values for the peak force developed, rate of force development ( dF dt ), and time to peak tension (TPT) were similar in both groups. Isoproterenol produced a significantly smaller ( p < 0.05) increase in peak force developed and dF dt in falling papillary muscles. The half equivalent dose (ED 50) of isoproterenol was flvefold higher in failing muscle as compared to normal muscle. We conclude that failing cardiac muscle demonstrates decreased responsiveness to β-receptor mediated stimulation.
Full Text 
Sign-in/Register to access full text options
Sign-in/Register to access full text options 
Published version (
Free)
Free) 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a call
