Abstract

Objective To disclose the relationship of neuronal protective effect and dift~rent time interval after nerve grafting reconstructed C5 root resection in young rats. Methods Mode] of C5 resection was set up in 18-day-old SD rats from Jauary 2009 to December 2009. Forty-eight rats with Cs resection were randomly divided into C5 resection group, immediate repairing group, three days delayed repairing group, and 6, 9, 12, 15, 18 days delayed repairing groups. Each group experienced nerve grafting bridged the C5 nerve root defection at its time interval. At 4 weeks postoperatively, the numbers of True Blue positively labeled neurons in all groups were counted respectively. Results There was no statistical difference among the number of proximal neuron of immediate repairing group and those of 3, 6 days delayed repair group (P 〉 O. 05) , but compared with C5 resection group, the number of neurons was statistically higher ( P 〈 0. 05 ). There was no statistical difference between the number of motoneurons of immediate repairing group and that of 9 days delayed repairing group(P 〉 0. 05 ), but there was statistical difference between sensory neurons of this two groups ( P 〈 0. 05 ). The neuron number of immediate repairing group was statistically higher than those of 12, 15, 18 days delayed repairing group(P 〈 0. 05). Conclusion Nerve reconstruction for C5 root injury in young rats within 0-9clays (equal to 0-6 months in hmnan beings) has a satisfactory protective effect on proximal neuron. It suggests that the OBPP children who have the operation indication should undergo surgical management in 6 months "after their birth. Key words: Brachial plexus ; Nerve injury ; Spinal cord ; Neuron ; Operative timing

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