Abstract
Nanofiber fabrication is attracting great attention from scientists and technologists due to its applications in many fields of life. In order to design a nanosized polymer-based drug delivery system, we studied the conditions for the fabrication of electrospun nanofibers from poly (vinyl alcohol) (PVA) and chitosan (CS), which are well-known as biocompatible, biodegradable and non-toxic polymers that are widely used in the medical field. Aiming to develop nanofibers that can directly target diseased cells for treatment, such as cancerous cells, the ideal choice would be a system that contains the highest CS content as well as high quality fibers. In the present manuscript, it is expected to become the basis for improving the low bioavailability of medicinal drugs limited by poor solubility and low permeability. PVA–CS nanofibers were obtained by electrospinning at a PVA:CS ratio of 5:5 in a 60% (w/w) acetic acid solution under the following parameters: voltage 30 kV, feed rate 0.2 mL/h, needle-collector distance 14 cm. The obtained fibers were relatively uniform, with a diameter range of 77–292 nm and average diameter of 153 nm. The nanofiber system holds promise as a potential material for the integration of therapeutic drugs.
Highlights
During the fabrication of PVA nanofibers from acetic acid solution, we found that the optimal parameters were 12% (w/w) PVA and 30% (w/w) CH3 COOH with the rest as deionized water
The investigation of nanofiber fabrication and rheological properties of the solutions containing PVA and CS polymers together with acetic acid as solvent showed that these factors were closely related to each other
While PVA and acetic acid reduced the conductivity of the solution, CS greatly increased the solution’s conductivity
Summary
In recent years, electrospinning technology has gained more and more attention along with the development of nanotechnologies, which have been used by scientists and technicians in a wide variety of scientific and technological fields. Due to its ability to function in a variety of forms, chitosan has attracted much attention line compounds [8]andand ensuring solubility in engineering dilute acidic in the fields of orthopedics periodontitis therapy [10,11], tissue [10–12],aqueo wound healing [10,12], and drug transport [10]. In biomedical applications, it has been [5,13]. The amino groups can be protonated, providing the chitosan with different properties of positive charges, it can adhere to both hard and compounds soft tissues such as passing through characteristic neutralization reactions of alkaline [8] such and ensuring solubility in dilutehydration, acidic aqueous hydrogen solutions
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