Abstract
The rat epididymal fat tissue was incubated with glucose differently labelled with 14C, and the effect of palmitate bound to albumin was studied in the absence or presence of insulin. No inhibition by palmitate of the glucose metabolism was observed. On the contrary, it was demonstrated that palmitate stimulates the different pathways of the glucose metabolism, particularly the fatty acid neosynthesis. The results are discussed in relation to the glucose and palmitate metabolism in the adipose cell, and in relation to the role in vivo of the adipose tissue in the decrease of the glucose assimilation observed in conditions which abnormally increase the serum level of free fatty acids.
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