Abstract
In this study, we observed the dynamic behaviors of microbubbles exposed to ultrasound using a high-speed camera (Ultranac, Nac, Japan). Although the maximum frame rate of the high-speed camera used in this study is 20 million frames/s, the possible frame rate was limited to 6 million frames/s because the high optical magnification of the observation system resulted in a shortage of light exposure to the camera. Behaviors of albumin-shelled microbubbles of 10–60 microns in diameter were clearly observed as in 24-frame sequential high-speed photographs at the maximum optical magnification of 85×. Several typical phenomena of bubble behavior, such as deformation and rupture of the bubble shell, anisotropic contraction of a microbubble and generation of a small stream, and fragmentation of a bubble by the small stream, were observed. From those observation results, it was concluded that the small stream generated by anisotropic contraction of a microbubble exposed to ultrasound causes fragmentation of the bubble in the contraction phase. [This research was partially supported by a grant-in-aid for scientific research from the Ministry of Education, Science, Sports and Culture, Japan.]
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