Study of the lipophilicity and retention behavior of some s-triazine derivatives on aminoplast and cellulose

Abstract

The chromatographic behavior of four groups of s -triazine derivatives (15 compounds) has been studied on aminoplast and cellulose thin layers with two mobile phases, methanol-water-acetonitrile, 30 + 20 + X , where X = 1–10 ( v/v ), and methanol-dilute acetic acid, 30 + 20 ( v/v ). The mechanism of retention was investigated by changing of volume fraction of acetonitrile in the first mobile phase. Reversed-phase chromatography occurs on both supports. Retention constants, R M o were determined by extrapolation and good correlation was obtained between retention constants, R M o and log P . These retention constants can be used as the measure of the lipophilicity of compounds. The effect of mobile phase pH on the chromatographic retention of s -triazine derivatives was examined and approximate protonation constants, pK a , were determined on the basis of the dependence of retention on pH. These constants correlated well with Hammett substituent constants σ .