Study of the levels of oxidative stress status in sera among Iraqi patients with type 2 diabetes

Abstract

Background: Chronic hyperglycaemia and cluster of lipid abnormalities associated with Type 2 diabetes (T2D), is defined by decreases in high-density lipoprotein (HDL) and increases in triglyceride (TG) and small, dense low-density lipoprotein (LDL) concentrations. Type 2 diabetes mellitus (T2DM) leads to increased lipid peroxidation in the body, followed by the development of chronic complications due to oxidative stress. The aim of this study was carried out to compare total antioxidant (TAO) levels and oxidative stress in type 2 diabetes mellitus (T2DM) patients with that of healthy controls without diabetes. Methods: A total of 93 participants (68 T2DM divided into three groups: group I (19) patients with diabetic duration (˂5 years), group II (19) patients with diabetic duration (≥5˃10 years), group III (30) patients with diabetic duration (≥10 years) and 25 healthy people) gave their consent and participated in the study. Thus, to achieve that, total oxidant status (TOS), total antioxidant status (TAS) and oxidative stress index (OSI), as well as the levels of fasting plasma glucose (FPG), glycosylated haemoglobin (HbA1c) and lipid profile were measured in patients group and the healthy individuals.