Study of the Kinetics of Sorption and Desorption of Doxorubicin Hydrochloride by Polymer Microspheres

Abstract

Introduction: One of the promising directions in the treatment of patients with malignant neoplasms is chemoembolization with microspheres, which consists in the local blocking of the blood flow by spherical particles and the release of a cytostatic drug by them in order to suppress the tumor. However, the pharmaceutical market is dominated by imported microspheres for embolotherapy, as a result of which they are characterized by a high cost. In this regard, the study of the properties of domestic embolisates is a popular topic for scientific research. Purpose: To study in vitro the kinetics of sorption and release of doxorubicin hydrochloride by polymeric microspheres of domestic production. Material and methods: Spectrophotometry was used to study the sorption kinetics and release of doxorubicin hydrochloride by polymeric microspheres. The appearance of the microspheres was examined by microscopy. Results and discussion: The study made it possible to establish the dependence of the rate of saturation of polymer microspheres «Sfera-Spektr» with doxorubicin hydrochloride on their size: the smaller the diameter of the microspheres, the faster they absorb the drug. The absence of dependence of the release rate of doxorubicin hydrochloride by polymeric microspheres on their size range was shown. Conclusion: The profiles of the sorption kinetics and the dynamics of the release of doxorubicin hydrochloride by polymeric microspheres have been established.