Abstract
The die-away curve after a single intravenous injection of [26- 14C]cholesterol was studied in normal chickens (standard diet) and in chickens with hypercholesterolaemia (0.5% cholesterol added to diet). The course of the curves indicates that plasma cholesterol turnover in chickens corresponds to the two-pool model. A kinetic analysis of the plasma cholesterol die-away curves in the terms of this model showed that a raised cholesterol intake led in chickens to (a) a decrease in the plasma cholesterol half-life (control: 23, cholesterol-fed group: 13 days), (b) an increase in the amount of cholesterol in the body pool with a rapid cholesterol turnover, (c) an increase in the fractional cholesterol turnover rate in this pool and (d) an increase in the total body cholesterol turnover.
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