Abstract
The interaction of trimethyltin(IV) with N,N,N’,N’-tetraethylethylenediamine (Et4en) was investigated potentiometrically. The hydrolysis constants of trimethyltin(IV) species and formation constants of the amine complexes are determined. The formation constant of the complex is high, which may suggest to use Et4en as an antidote for triorganotin(IV) poisoning, the main source of marine environmental pollution. The effect of solvent dielectric constant of the medium and temperature on the complex formation equilibria was investigated.
Highlights
In the last two decades coordination compounds of organotin(IV) exhibit interesting antitumoural activity against several human cancer cell lives(Zhu et al, 2004) and some of them are are extremely toxic to animals and humans (Cardiano et al, 2008, Nolan et al, 2005)
There is a need to study their complex formation equilibria with a hope to find an antitode for it. With this in mind and in conjunction with our previous studies (Shoukry, 2002; Shoukry et al, 1995; Shoukry et al 2000; Shoukry et al 1995; Shoukry et al 1986), on metal complexes of biological significance, the present paper includes the results of the study of trimethyltin(IV) complexes with N,N,N’,N’-tetraethylethylenediamine
The acid-dissociation constants of the amine in the protonated form were determined under the same experimental conditions of ionic strength (0.1M) and temperature (25 °C) used for the study of trimethyltin(IV) complex equilibria
Summary
In the last two decades coordination compounds of organotin(IV) exhibit interesting antitumoural activity against several human cancer cell lives(Zhu et al, 2004) and some of them are are extremely toxic to animals and humans (Cardiano et al, 2008, Nolan et al, 2005). The deleterious effect of trialkyltin(IV) derivatives is due to the inhibition of mitochondrial oxidative phosphorylation (Aldridge, 1976) and the ability to bind certain proteins (Elliott et al, 1979).The toxicity of tetra-alkyltins appears to be due trialkyltin(IV) species which are produced as a result of dealkylation in vivo. For these reasons, significant attention is paid to environmental pollution by alkyltin compounds and to their presence in food. There is a need to study their complex formation equilibria with a hope to find an antitode for it. The complex formation equilibria is investigated with the hope that such type of coordinating ligand might possess favorable properties, possibly as carries in body fluids
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