Abstract
The effects of sulfur dioxide (SO 2) derivatives (bisulfite and sulfite, 1:3 M/M) on voltage-dependent sodium channel in isolated rat ventricular myocyte were studied using the whole cell patch-clamp technique. SO 2 derivatives increased sodium current ( I Na) in a concentration-dependent manner. SO 2 derivatives at 10 μM significantly shifted steady-state inactivation curve of I Na to more positive potentials, but did not affect the activation curve. SO 2 derivatives markedly shifted the curve of time-dependent recovery of I Na from inactivation to the left, and accelerated the recovery of I Na. SO 2 derivatives also significantly shortened the activation and inactivation time constants of I Na. These results indicated that SO 2 derivatives produced concentration-dependent stimulation of cardiac sodium channels, which due mainly to the interaction of the drug with sodium channels in the inactivated state.
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