Study of the interaction of ibuprofen with various polymers

Abstract

Nonsteroidal antiinflammatory drugs are widely used in modem medicine for the treatment of various disorders. A special place in this group belongs to ibuprofen, which has been used since 1969 and is recognized as an effective low-toxicity analgesic. At the same time, ibuprofen is not free of disadvantages inherent in all drugs capable of inhibiting the cytoprotective isoenzyme cyclooxygenase. The main drawbacks are a decrease in the level of prostaglandins in the mucous membranes of the gastrointestinal tract and the related ulceration effect, which is especially pronounced in the case of prolonged administration of these nonsteroidal antiinflammatory drugs [ 1, 2]. Since ibuprofen is available without special prescriptions and can be used by patients for a long time without regulation, medicinal forms of this drug must be developed so as to exhibit minimum side effects [3]. There are several commonly accepted methods used by 9 modem pharmacy in order to reduce the irritating action of drugs. This goal is mostly achieved by using supplementary components improving the solubility of the drugs or restricting the area of contact between drug and mucous membrane. Various high-molecular-weight compounds (polymers) are among these substances. The purpose of this work was to study the interaction of ibuprofen with various polymers and select substances providing a maximum decrease in the irritating effect of this drug.