Study of the insulin gene in children with insulin-dependent diabetes mellitus in the Azerbaijani population

Abstract

Insulin-dependent diabetes mellitus is autoimmune disease and in persons with an identical genotype frequency of its occurrence can be up to 70%. In the hereditary transmission of the disease, special loci are involved, which are called IDDM1, IDDM2, etc. The IDDM2 gene belongs to the INS gene.The objective: the study of the insulin gene in representatives of the Azerbaijani population.Patients and methods. The insulin gene was studied in 160 children with diabetes mellitus type 1, and in 271 healthy people from the Azerbaijani population. Of the 160 patients, 50.6% (n = 81) were boys, 49.4% (n = 79) were girls. All patients with diabetes were under the age of 18 years. The average age of the patients was 9.1 years. The survey was conducted on the basis of children’s clinical hospital number 6 in Baku city. For all patients, a special questionnaire was filled out. Only children of Azerbaijani nationality were included in the study. As a comparison group, 271 students from the Medical College No. 1 in Baku were involved. Of these: 29.1% (n = 79) were boys, 70.9% (n = 192) girls.Results. Collected blood samples were sent for further study by the medical genetic laboratory of the University Hospital of Motol at Charles University, located in the city of Prague (Czech Republic).Conclusion. According to the data obtained in our study, it can be argued that in the Azerbaijani population the insulin gene 23HphI does not play a role in the development of diabetes mellitus.