Abstract
The present study work investigates the effect of infertility drugs, clomiphene citrate (CC) and humegon, on the function of vital body organs. This study has been accomplished using 60 albino rats (30 male, 30 female), which have been divided into three groups 20 animal (10 male, 10 female) for each group. The first group fed daily with 50mg of clomiphene citrate by intragastric gavage for 30 days. The second group fed daily with 50mg of clomiphene citrate for 30 days, and then injected with 75 IU of humegon for 10 days. The animals were killed after the scheduled time and the required tests have been conducted in the laboratories of college of science and Al-Ramady teaching Hospital. Many biochemical and histological changes were induced in these animals when treated with CC or CC with humegon. The biochemical tests included, Uric acid, Creatinine and Electrolytes. The treated animals showed a significant decrease in Uric acid, Creatinine and Electrolytes. The light microscopic examination of Kidney showed glomerular hypertrophy, tubular necrosis, inflammatory infiltration and dilated blood vessels.
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