Study of the impact of amino acids hydrochloride forms on the formation of biomimetic composites in the presence of nanocrystalline hydroxyapatite

Abstract

The study of molecular composition of the biomimetic composites on the basis of nanocrystalline carbonate-substituted (C-HAP) and polar amino acids of L-lysine hydrochloride and L-arginine hydrochloride was performed in the work. Results of the study show that the change in acidity of the medium (pH≥11.2, ≥7.55 и ≤5) occurs under transformation of the conformational environment of L-lysine hydrochloride molecules with the formation of L-lysine structure as while increase of pH level as in the presence of C-HAP nanocrystals. At the same time composites basing on L-arginine keep their amorphous structure in the presence of synthesized C-HAP in the different media. The detected differences in the molecular environment of hydrochloride forms of amino acids during the interaction with nanocrystalline C-HAP prove to be significant for the development of technology of the integration between biocomposites and hard dental tissues.