Abstract
Abstract This experiment was designated to study the effect of mentha piperita on hypercholesterolemic female rats. 25 femal rats weighing 139.40±8g were classified into control (-ve) and 4 hypercholesterolemic rat groups fed on unsaturated fats and egg yolk powder. 5 rats of them served as control (+ve) whiles the rest of them were treated with mentha oil, extract and powder. The period of the experiment was 45 days. In comparing with control (+ve) group, the obtained results revealed that female rat groups which treated with mentha oil, extract and powder showed improvement in nutritional and some kidney and liver function. Also, they showed a significant decrease in total cholesterol, triglyceride, low density lipoprotein cholesterol , very low density lipoprotein cholesterol, total lipids , phospholipids and atherogenic indexes but significant increase in high density lipoprotein cholesterol. Moreover, they showed significant decrease in malondialdehyde and significant increase in superoxide dismutase, glutathione and progesterone but non significant difference of testosterone. Histopathological results showed pathological changes of liver and ovaries in control (+ve) group but these changes were improved in female rat groups which treated with mentha oil, extract and powder. Key words: Mentha piperita - hypercholesterolemic - liver and kidney functions - sex hormone- rats.
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