Abstract
AbstractNew cross‐linked polyacrylic supports, functionalized with methoxycarbonyl groups (from 0,2 to 6,0 mmol · g−1), were prepared. The reaction with ethylenediamine was realized in two ways: action of neat ethylenediamine or use of coupling agents. The yield depends on the initial loading with methoxycarbonyl groups and on the length of the spacer group. The percentage leading to the formation of side reactions of bridges, and that of unreactive methoxycarbonyl residues depends on steric factors. These results are of importance for the preparation of supports adapted to the solid phase peptide synthesis.
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