Study of the expression of metastasis-associated in colon cancer 1, thymidine kinase 1 and the clinical significance of prostate carcinoma

Abstract

Objective To investigate the expression of metastasis-associated in colon cancer 1 (MACC1), thymidine kinase 1 (TK1) in prostate carcinoma tissues and their effect on the development of prostate carcinoma. Methods The expression levels of MACC1 and TK1 in 70 cases of prostate carcinoma tissues and 20 cases of benign prostatic hyperplasia tissues were detected by using immunohistochemical method, the relationship between the levels of MACC1, TK1 and the clinicopathological features of prostate carcinoma were analyzed. Results The expression rate of MACC1 in prostate carcinoma tissues was higher than that of benign prostatic hyperplasia tissues (61.43% vs. 20.00%, t=10.700, P=0.000), the expressions of MACC1 were related prostate carcinoma to histology grade, Clinical stage and seminal vesicle invasion (Respectively, t=8.930, P=0.010, t=6.720, P=0.010, t=4.850, P=0.030); The expression rate of TK1in prostate carcinoma tissues was higher than that of benign prostatic hyperplasia tissues (64.29% vs. 15.00%, t=15.180, P= 0.000), the expressions of TK1 were related prostate carcinoma to histology grade and Clinical stage (Respectively, t=7.290, P=0.030, t=6.790, P=0.010). Conclusion MACC1 and TK1 might be play an important role in the invasion and metastasis in prostate carcinoma. Key words: Metastasis-associated in colon cancer 1; Thymidine kinase 1; Prostate carcinoma; Immunohistochemical method