Abstract
Cronos is a recently discovered isoform of the giant protein titin driven by an alternative internal promoter. Cronos spans the half-A-band of a sarcomere and binds to myosin filaments, but its role in healthy or diseased hearts is largely unknown. Upregulation of Cronos has been suggested as a possible compensatory mechanism in titin-truncation cardiomyopathy, to help explain why truncations in titin's I-band region are less frequent and often cause a milder disease phenotype than truncations in the A-band region.
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