Study of the Effectiveness of Drug No. 5 in a Model of Dry Eye Syndrome in Rabbits.

Abstract

It was shown that in the model of dry eye syndrome (DES) in rabbits, if drug No. 5 was instilled in both eyes of animals at a dose of 0.05 mL/kg in 1:15 dilution with sterile saline solution twice a day for 30 days, then it had a strong anti-inflammatory, wound-healing, and angioprotective effects. This positively affected the course of reparative process in the conjunctiva and cornea complicated by nonclosing of the eyelids. It was also found that drug No. 5 in the tested dose promoted the stimulation of reparative processes in the conjunctiva and cornea, clinically manifesting itself in accelerating the recovery of defects in the anterior epithelium and corneal stroma, and in reducing both frequency of formation of deep corneal defects and severity of inflammatory response and vascularization. There was a slowdown in the formation of corneal opacities, a decrease in the amount and appearance of a more liquid mucous discharge of the conjunctiva compared to the control. It was also demonstrated in the stated model of DES that drug No. 5 in the test dose had a pronounced pharmacological effect, contributing to a faster recovery of damage to the superficial epithelium and stroma of the cornea, anterior and posterior chambers of the eye, the vascular membrane and retina as well as goblet cells of the conjunctiva.