Study of the effectiveness of a new antifungal agent for the treatment of animal dermatophytosis

Abstract

Relevance. Small domestic animals often suffer from dermatophytosis chronically, while remaining active carriers. In clinical medicine, there is a certain arsenal of drugs with antifungal activity, both ofsystemic and local action, the use of which often causes side effects. In this regard, the search, development and implementation in public health and veterinary practice of highly active and low-toxic drugs that can specifically affect pathogenic fungi without adverse effects on the body is relevant. On the basis of screening microbiological studies, a thiadiazole derivative was selected, which in preliminary experiments showed antifungal activity.Methods. The study was conducted on the basis of the St. Petersburg State Chemical Pharmaceutical University for 21 days. 19 cats in the analyzes of which a fungus Microsporum canis was detectedwere used in the experiment. An ointment based on a thiadiazole derivative was rubbed into the affected area of the skin once a day in an amount of 0.01–0.05. The therapeutic efficacy of ointments was evaluated for 21 days according to the following parameters: specific glow of lesions in the rays of a Wood's lamp in the presence of a pathogen; results ofseeding and microscopic examination of the material; coat recovery time; local irritant action.Results. When animals were treated with 3% thiadiazole ointment, on the 10–12th day the inflammation regressed, and abundant small-lamellar peeling was observed on the skin in the foci. By 12–15th day the surface of the foci was cleared, and the skin acquired a pale pink color. The restoration of the coat was observed at the end of the application of the ointment — on 21st day. The specific glow of regrown hairs in the rays of the Wood's lamp ceased. The results of seeding and microscopy of regrown hairs became negative. Negative reactions when applying the ointment to the skin of animals were not observed. The results of the study indicate high efficacy and good tolerability of 3% thiadiazole ointment.