Study of the effect of laurel plant (Laurus Nobilis) on some biochemical markers in diabetic mellitus rats

Abstract

The present study is aimed to introduce the effect of laurus nobilis extracts on blood glucose level, liver function, lipid profile, and body weight in diabetic rats. Three experiment was done for seventy- two albino male rats (150-200) grams were divided into twelve groups, in each study experiment rats were divided to four groups (6 rats for each) , first group treated with distilled water and served as control group, second group served as positive diabetic and treated with 100 mg/kg, BW single dose of alloxan. Third group treated with 250 mgkg of oil, flavonoids and tannins extracted from Laurus nobilis, while fourth group was served as diabetic and treated with 250 mgkg b. w of laurus nobilis extract, all groups were treated orally, the following results were evaluated, fasting blood glucose, triglyceride (TG), total cholesterol (TC), high density lipoprotein-cholesterol (HDL-c), low density lipoprotein-cholesterol (LDL-c), very low density lipoprotein-cholesterol (VLDL-c), alanine aminotransferase (ALT), aspartate aminotransferase (AST), alkaline phosphatase (ALP) and body weight .After 4 weeks of treating by250 mgkg BW bay leave extracts there was significant decrease in fasting blood glucose , TG, TC, LDL, VLDL, ALT, AST, ALP, and a significant increase in HDL and body weights.