STUDY OF THE EFFECT OF FICUS CARICA PLANT AGAINST STAPHYLOCOCCUS AUREUS BACTERIA

Abstract

Objective: Antibiotic resistance is an important epidemiological problem that is on the global agenda and solutions are sought. As the morbidity and mortality rates caused by this problem increase every year, studies on developing new alternative active molecules are gaining momentum. Theoretical Framework: Determining the antibacterial activity of the fig (Ficus carica), which has bioactive content and is the first in production in the world, against methicillin-resistant Staphylococcus aureus bacterial strain, which is the leading antibiotic resistance, by computer-based molecular docking studies. Method: The binding energies of the interaction of the protein that causes antibiotic resistance in MRSA strains with the molecules of the fig plant were detected. Among the molecules with high binding energy in the protein-ligand structure, those are suitable for the drug likeness parameters were evaluated. Results and Discussion: Molecules with high affinity and sufficient bioavailability of bioactive molecules found in fig can be developed and used in alternative antibiotic studies. The findings obtained will support in vivo and in vitro studies on the antibacterial activity of figs and bring different perspective to new studies. Research Implications: Molecular docking study with 177 active molecules of the Ficus carica plant, 4 candidate active molecules that passed the druglikeness parameters and showed high binding energy were determined as quercetin, kaempherol, coumarins and riboflavin. Originality/Value: It is envisaged that the studies of these candidate molecules, which have been identified, will contribute greatly to experimental studies in terms of both time and cost.