Abstract
Berberine chloride is an isoquinoline alkaloid that has antimicrobial activity against bacteria, viruses, chlamydia, fungi, protozoans, and helminths, etc. The study was designed with the aim to evaluate the influence of the Trivedi Effect®- Consciousness Energy Healing Treatment on the physicochemical and thermal properties of berberine chloride by using modern analytical techniques. For this study, the berberine chloride sample was divided into two parts among which, one part was named as control as no Biofield Energy Treatment was given to it; while the other part received the Consciousness Energy Healing Treatment remotely by a renowned Biofield Energy Healer, Alice Branton and named as the Biofield Energy Treated sample. The PXRD results revealed some changes in the Bragg’s angle of peaks along with - 7.24% to 188.78% alterations in the peak intensities and -65.88% to 135.42% changes in the crystallite sizes of the treated sample. Also, there was 1.91% decrease in the average crystallite size of the treated sample compared to the control sample. The particle size of the treated sample was significantly reduced by 20.16% (d10), 17.21% (d50), 27.53% (d90), and 27.36% {D(4,3)}; along with 15.31% increase in the specific surface area compared with the control sample. The total weight loss was significantly reduced by 25.81%; however, the residue amount was significantly increased by 55.04% in the treated sample compared to the control sample. Besides, the DSC thermogram showed four peaks, in which the peak temperatures of the treated sample corresponding to 1st, 2nd, 3rd, and 4th peak were altered by -2.26%, 3.55%, - 4.50%, and -0.69%, respectively. Moreover, the latent heat for 1st, 2nd, 3rd, and 4th peak of the treated sample were significantly reduced by 24.04%, 42.44%, 44.26%, and 47.78%, respectively, compared with the control sample. The results showed that the Trivedi Effect®-Consciousness Energy Healing Treatment might help in improving the solubility, absorption, and bioavailability of berberine chloride compared with the control sample. Hence, the Consciousness Energy Healing Treatment would be useful for designing the novel nutraceutical/pharmaceutical formulations of berberinechloride with improved drug profile for the treatment of various microbial diseases and disorders such as diarrhea, gastroenteritis, hypertension, tumor, malaria, hyperglycemia, inflammation, arrhythmia, infections, etc.
Highlights
Berberine is an isoquinoline alkaloid and is derived from the stem and root of various medicinal plants such as Hydrastis canadensis, Berberis aristata, Berberis aquifolium, Coptis japonica, Phellodendron amurense, and Berberis vulgaris, etc. [1]
The results showed that the Trivedi Effect®-Consciousness Energy Healing Treatment might help in improving the solubility, absorption, and bioavailability of berberine chloride compared with the control sample
It was observed that the peak intensities of those peaks of the Biofield Energy Treated sample were significantly altered ranging from -7.24% to 188.78% in comparison to the control sample
Summary
Berberine is an isoquinoline alkaloid and is derived from the stem and root of various medicinal plants such as Hydrastis canadensis, Berberis aristata, Berberis aquifolium, Coptis japonica, Phellodendron amurense, and Berberis vulgaris, etc. [1]. Berberine is an isoquinoline alkaloid and is derived from the stem and root of various medicinal plants such as Hydrastis canadensis, Berberis aristata, Berberis aquifolium, Coptis japonica, Phellodendron amurense, and Berberis vulgaris, etc. The use of berberine has been evident for its antimicrobial activity against bacteria, viruses, fungi, chlamydia, protozoans, and helminths, etc. In traditional Eastern medicine, it is widely used for centuries as a treatment against diarrhoea and gastroenteritis [2]. Berberine has a wide range of pharmacological activities and is used for various ailments related to skin and eye [3,4]. Berberine hydrochloride is used as diaphoretic, antiplasmodial [5,6], anti-hypertensive [7], anti-malaria [8], anti-arrhythmic [9,10], antitumor [11,12], anti-hyperglycemic [13], anti-inflammatory [14,15], antioxidative [16], antifungal [17], and cerebro-protective [18] activities. Some studies reported its role in reducing the lipid and cholesterol accumulations in the liver as well as in the liver [19]. Berberine is used in clinical practice in the form of its salts i.e., berberine chloride and berberine sulfate in the form of immediate release tablet and capsule [20]
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