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Abstract
In order to study both direct and pituitary-mediated mechanisms of action of the LHRH analogue [D-Ser(TBU) 6, des-Gly-NH 2 10] LHRH ethylamide upon testicular steroidogenesis in adult rat, we compared the effects of the agonist when administered alone or concomitantly with an anti-LH serum to non-hypophysectomized rats. Testicular steroid contents and in vitro progesterone and testosterone metabolism were determined. Anti-LH serum administration was able to prevent 5 α-reductase stimulation by the agonistic peptide, but not the inhibition of 17-hydroxylase activity. These data suggest that modulation of 17-hydroxylase involves both direct and pituitary-mediated processes, while 5 α-reductase stimulation is mainly if not only due to a pituitary-mediated mechanism.
Published Version
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