STUDY OF THE CONTRIBUTION OF GENES NERVOUS SYSTEM RELATED TO HEART FAILURE

Abstract

Objective: Heart Failure (HF) is a complex syndrome that can be amplified by pathology associated with the nervous system. This study aims to investigate the contribution of genetic polymorphisms of Brain Derived Neurotrophic Factor (BDNF, rs6265), Neurotrophic Receptor Tyrosine Kinase 2 (NTRK2, rs2289656) and Neural Growth Factor (NGF, rs6330) genes in the development of HF. Design and method: A case-control study was conducted with a population of 261 individuals, of which 131 had HF (66 women and 65 men) with a median age of 77 years (Min = 31 years and Max = 96 years) and a BMI median of 25,00 Kg/m2 (Min = 17,80 Kg/m2 and Max = 47,30 Kg/m2), and 130 controls (113 women and 17 men) with a median of age 60,50 years (Min = 44 years and Max = 84 years) and a median BMI of 29,09 Kg/m2 (Min = 14,19 Kg/m2 and Max = 47,30 Kg/m2). Analyses of the 3 polymorphisms were performed using the Genotyping Endpoint PCR technique. Statistical analysis was performed using IBM software® SPSS® Statistics 28.0, with a statistical significance level set at p < 0,05. Results: For the rs2289656 polymorphism of the NTRK2 gene, the GG genotype was found to be a risk factor for HF [OR (CI, 95%) = 3.029 (1.053 – 8.718); p = 0.040]. The association between the presence of the A allele of the NTRK2 gene and HF [OR (CI, 95%) = 0.330 (0.115 – 0.950); p = 0.040] was also verified, with this allele constituting a protection factor. Regarding BDNF and NGF gene polymorphisms, no statistically significant differences were found. These results were adjusted for age, BMI and gender. Conclusions: These results show an association between the NTRK2 gene and HF, suggesting that this gene variation may enhance the development of HF. The identification of genetic polymorphisms that may somehow influence the development and severity of HF may allow its faster diagnosis and the application of methodologies for disease prevention. Moreover, our results will contribute to define a genomic profile associated with the role of the nervous system in HF.