Abstract
Currently magnetic resonance imaging (MRI) is one of the key diagnostics methods of various diseases. Utilizing various contrast agents based on magnetic nanoparticles can improve the diagnostic efficiency and, consequently, the quality of the subsequent treatment. The most promising contrast agents are cubic magnetite nanoparticles, due to their high relaxation rates, as well as biocompatibility and biodegradability. Thereby, the purpose of this work was to evaluate the effectiveness of MRI imaging of tumors by cubic magnetite nanoparticles (CMN). Materials and methods. For this purpose, the synthesis of 15 nm CMN modified with biocompatible copolymer plurlonic F127 was carried out. Synthesized CMN and their water colloids were characterized by a complex of physicochemical methods of analysis. Then, using MRI a study of the effectiveness of contrasting of various tumor types after intravenous administration of CMN aqueous colloids was made. Three models of mouse tumors were used for a comprehensive assessment of obtained results: breast cancer 4T1, colon cancer CT-26 and melanoma B16. MRI studies were performed prior to the administration of the particles, and also after 15 min, 6 hours and 24 hours after injection in T2-weighted regime in two mutually orthogonal projections. Results. The analysis of the obtained results showed that the most effective accumulation of particles was found in the 4T1 (100%) and B16 (57%) models, and in the case of CT-26 model the accumulation efficiency was 50% due to the effect of the permeability of blood vessels.
Highlights
Utilizing various contrast agents based on magnetic nanoparticles can improve the diagnostic efficiency and, the quality of the subsequent treatment
Thereby, the purpose of this work was to evaluate the effectiveness of magnetic resonance imaging (MRI) imaging of tumors by cubic magnetite nanoparticles (CMN)
The synthesis of 15 nm CMN modified with biocompatible copolymer plurlonic F127 was carried out
Summary
Изучение ýффективности контрастирования различных видов опухолей с использованием кубических наночастиц магнетита. Использование различных контрастных агентов на основе магнитных наночастиц способно повысить эффективность диагностики и, как следствие, качество проводимого впоследствии лечения. Затем методом МРТ было проведено исследование эффективности контрастирования различных видов опухолей после внутривенного введения водных коллоидов КНЧМ. Магнитно-резонансная томография (МРТ) – метод, широко применяемый в клинике для диагностики различных заболеваний, в том числе онкологических [1, 2]. В настоящее время ведется активная разработка Т2- и Т1-контрастных агентов для повышения ýффективности диагностики опухолей методом МРТ. Ранее в работах было показано, что кубические наночастицы магнетита превосходят наночастицы других форм по показателю Т2-релаксации и тем самым являются более предпочтительным контрастным агентом для применения в МРТ-визуализации опухолевых очагов [8, 9]. Однако EPR-ýффект существенно варьирует как в разных опухолях, так и для разных пациентов [12], что диктует необходимость комплексной оценки контрастирующих свойств кандидатных диагностикумов в различных опухолевых моделях in vivo
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