Study of the chemical compatibility of two active substances and stability of their solution

Abstract

The metabolic field aiming at theoretical and applied analysis of metabolic processes of different levels to be the basis or the background of many diseases has been actively developing for the last decade. Especially, the concepts of the role of the cell energy metabolic imbalance during various pathologic processes that are based, first of all, on the mitochondrial deficiency have been actively developed.The irreversible cell damage when affected by the disturbing agents occurs from the moment of damage of organelles- the ATP generating cell systems. The paper studies the opportunity of creating the combined dosage formulation containing two active pharmaceutical ingredients (succinic acid and butafosfan) based on their chemical compatibility. The literature contains no information concerning the use of butafosfan and succinic acid in the same dosage formulation. Butafosfan improves the blood glucose disposal that stimulates the energy metabolism and accelerates metabolic processes due to the ADP-ATP cycle stimulation. Succinic acid can directly improve the energy-synthesizing function of mitochondria by increasing the succinate delivery and consumption by ischemic cells, participate in implementation of the succinic acid quick oxidation by succinate dehydrogenase, as well as activation of the mitochondrial respiratory chain leading to the ATP quick resynthesis. One of the obligatory phases of research is identification and study of physical and chemical properties of the active ingredient, compatibility assessment of the active ingredient and excipients, and in case of combination drugs - also compatibility assessment of ingredients themselves. To choose the necessary conditions during the solution technology development, the chemical properties, stability and compatibility of these pharmaceutical substances were studied.