Study of the Biologically Active Properties of Medicinal Plant Cotinus coggygria.

Stanislav Sukhikh,Artem Pungin,Svetlana Ivanova,Olga Babich,Svetlana Noskova,Liubov Skrypnik,Evgeny Chupakhin

doi:10.3390/plants10061224

Stanislav Sukhikh, Artem Pungin + Show 5 more

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https://doi.org/10.3390/plants10061224

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Abstract

The results of the studies have shown that to obtain an extract of a complex of biologically active substances of Cotinus coggygria, ethyl alcohol (mass fraction of alcohol 70%) with a hydromodule of 1:5 should be used, and the extraction should be carried out for 60 min at a temperature of 60 °C. The investigated plant extracts with the complex of bioactive substances from the Cotinus coggygria leaves and flowers are safe from the point of view of the content of heavy metals, pesticides, aflatoxin B1, radionuclides, as well as pathogenic and opportunistic microorganisms. It has been established that the Cotinus coggygria extract contains rutin, hyperoside, ferulic acid, quercetin, kaempferol, disulphuretin, sulphurein, sulphurein, gallic acid, methyl gallate, pentagalloyl glucose, 3,3′,4′,5,6,7-hexahydroxyflavonone, 3,3′,4′,5,5′,7-hexahydroxyflavonone, 3-O-α-L-rhamnofuranoside, 3,3′,4′,5,5′,7-hexahydroxyflavulium(1+), 7-O-β-D glucopyranoside, and 3,3′,4′,7-tetrahydroxyflavonone. The tested extracts have anticancer, antigenotoxic, and antimicrobial (against E. coli, S. aureus, P. vulgaris, C. albicans, L. mesenteroides) properties. The high antioxidant status of the tested extracts was established; the antioxidant activity of the samples was 145.09 mg AA/g (AA—ascorbic acid).

Highlights

Academic Editors: Lina Raudone and Institute of Living Systems, Immanuel Kant Baltic Federal University, A
Significant differences (p > 0.05) in the extract yield (Tables 1 and 2) with an extraction duration of up to 360 min were found at a hydromodule ratio of 1:5 in comparison with samples obtained at other hydromodule ratios
At a hydromodule value of 1:5, no statistically significant differences were found with an extraction duration of 60 min or more

Summary

Introduction

Secondary metabolites—iridoids, phytoncides, tannides, flavonoids, essential substances, nitrogen-containing compounds, glycosides, and organic acids—have unique antibacterial, antioxidant, and other properties that allow using medicinal plants in food, pharmaceutical, feed, and other industries [1,2]. Natural products produced by higher plants as secondary metabolites are a rich source of biologically active compounds that can be used to develop new chemicals for pharmaceuticals. It should be noted that the biological activity depends on the qualitative and quantitative composition of the secondary metabolites of the medicinal plant, which is not constant [5]. The Baltic states with a temperate climate and small anthropogenic impact have the potential to grow plants with unique characteristics of both qualitative and quantitative content of biologically active components [7]

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