Abstract

Abstract The procedure developed by Barkan and Kunze was used to analyze uncoated reserpine tablets representing 108 formulations from 60 drug manufacturers. To assay certain products, changes in the original method were required because of interferences from excipients; these changes involved column and sample preparation. The standard deviations of the modified procedure were 1.54% of declared (ultraviolet assay) and 0.90% of declared (colorimetric assay) at the 0.25 mg/tablet level.

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