Study of the Antimicrobial Potential of Bacteria found in Natural Resources

Svetlana Noskova,Elena Ulrikh,Lyubov Dyshlyuk,Stanislav Sukhikh,Svetlana Ivanova,Olga Babich,Alexander Prosekov,Margarita Shevchenko

doi:10.22207/jpam.15.2.28

Abstract

Bacteriocins are of great interest as potential antimicrobial agents against various types of bacteria, fungi, and viruses. Isolates of microorganisms derived from natural sources were used in the current study, including lactic acid bacteria and other antagonistic microorganisms. The species of the microorganisms were determined using 16S rDNA and ITS nrDNA analyses. E. coli, S. enterica, S. aureus, P. aeruginosa, B. mycoides, A. faecalis, P. vulgaris, S. flexneri , L. monocytogenes, C. albicans, A. flavus, and P. citrinum were used as pathogenic and opportunistic strains. It was found that 11 strains of antagonistic microorganisms have significant antimicrobial activity against all pathogenic and opportunistic microorganisms. The antimicrobial properties of these microorganisms are currently under study.

Highlights

The discovery of antibiotics was a major breakthrough in treating infectious diseases, significantly improving the quality of life and longevity worldwide
This study aims to evaluate the antimicrobial potential of antagonistic microorganisms
The largest number of strains of lactic acid bacteria and other antagonistic microorganisms were isolated from the soil and natural water bodies (Table 1), including B. subtilis, P. glabrum, P. koreenis, P. ochrochloron, L. mesenteroides, P. acidilactici, P. pentosaceus, B. hypermegale, B. ruminicola, P. damnosus, B. paurosaccharolyticus, G. stearothermophilus, and B. caldotenax

Summary

Introduction

The discovery of antibiotics was a major breakthrough in treating infectious diseases, significantly improving the quality of life and longevity worldwide. After several years of antibiotic use, resistance to antimicrobials emerged. Its spread has become a severe health problem.1Gram-positive and gram-negative bacteria are increasingly showing multidrug resistance to the main antibiotics and drugs used in clinical practice, such as drugresistant methicillin-resistant Staphylococcus aureus, resulting in higher morbidity and mortality than usual.[2,3,4] Multidrug resistance of enterococci to vancomycin has been reported. Drug resistance has placed a burden on patient health and the economies of hospitals and communities, indicating the need for developing new antibiotic drugs. Rational use of existing antibiotics could alleviate this problem.[5]

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