Abstract
Study of the Antifibrotic Effect of Olmesartan on the Carbon Tetrachloride- Induced liver Toxicity in Rats
Highlights
Liver is composed of a parenchyma and stroma
Each lobule is composed of central vein and cords of hepatocytes that radiate from the central vein towards the corners of the hexagonal lobule
The light microscopic examination of the rat's liver of the control group showed arrangement of hepatocytes in cords radiating from the central vein, separated by hepatic blood sinusoids which were lined by Kupffer cells
Summary
Liver is composed of a parenchyma and stroma. The parenchyma is formed of multiple similar subunits called liver lobules. Each lobule is composed of central vein and cords of hepatocytes that radiate from the central vein towards the corners of the hexagonal lobule At this corner, there are the portal triads; each tract is a small triangular area containing a bile duct, hepatic artery and portal vein that are enclosed by connective tissue (Sage et al, 2007). Olmesartan is an antihypertensive agent, which belongs to the class of medications called angiotensin-II receptor blockers. It is indicated for the treatment of high blood pressure (Tombolini and Cingolani, 1996). Administration of Olmesartan medoxomil prevented the increase in liver peroxidation caused by carbon tetrachloride induced liver damage as lipid peroxidation is one of the primary events of carbon tetrachloride (Recknagel, 1976). The administration of olmesartan medoxomil to patients with mild alcoholic liver disease improved the abnormal liver function tests more rapidly than in patients receiving a placebo (Salmi and Sarna, 1982)
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