Study of the Anti-Diuretic Hormone (ADH) on End Stage Renal Failure Disease (ESRD) Pre-Hemodialysis in Iraqi Patients

Tiba A Kh Al-Taiee,Adnan Abduladheem Aljber,Nawal M.J Al-Shammaa

doi:10.30526/32.2.2135

Tiba A Kh Al-Taiee, Adnan Abduladheem Aljber + Show 1 more

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https://doi.org/10.30526/32.2.2135

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Abstract

Chronic renal disease (CRD) is a pathophysiologic process with multiple etiologies, resulting in the inexorable attrition of Nephron number and function and frequently leading to end-stage renal disease (ESRD). In turn, ESRD represents a clinical state or condition in which there has been an irreversible loss of endogenous renal function, of a degree sufficient to render the patient permanently dependent upon renal replacement therapy (dialysis of transplantation) in order to avoid life threatening uremia, reflecting a dysfunction of all organ systems as a result of untreated or under treated acute or chronic renal failure. The current study was involved 80 patients, the age range within 25-70 years, selected sample of patients who attend Iraqi center of kidney dialysis, Baghdad Teaching Hospital and Al-Yarmok Teaching Hospital. All the patient's body mass index [BMI] were measured serum anti diuretic hormone ADH was assessed using enzyme linked immunosorbent kit [Elisa] while urea, creatinine, albumin, hemoglobin were determined by spectrophotometer (PD-303), and sodium, potassium, chloride were determined by Electrolyte analyzer 9180.These patients were divided in two group B (40 patients) as pre dialysis with ESRD, and group A (40) healthy control. Results showed non-significant elevations in ADH levels in the patient group compared with the control group, while highly significant increase in urea, creatinine and albumin levels in in the patient group compared with the control group, also highly significant decrease in hemoglobin comparing with the control group. Also, it was observed non-significant decrease in sodium, non-significant increase in potassium and highly significant increase in chloride when comparing with the control group.

Highlights

Antidiuretic hormone (ADH) is a hormone secreted by the posterior lobe of the pituitary gland, in the brain
Results showed a non-significant increase in Group B (GB) when comparing with Group A (GA) in ADH, while highly significant increase in GB comparing with GA in urea, creatinine and albumin, highly significant decrease in GB when comparing with GA in hemoglobin as shown in Table 1, and Figure 1
Earlier data showed to patients End Stage Renal Failure Disease (ESRD) before dialysis sera ADH, urea and creatinine levels are higher than healthy control

Summary

Introduction

Antidiuretic hormone (ADH) is a hormone secreted by the posterior lobe of the pituitary gland, in the brain. ADH moves in the blood and reaches to its target organ, the kidney It is a key hormone in human body serving important physiological functions such as homeostasis of fluid balance and regulation of the endocrine stress response. There are several important roles of sodium in the body, but the abundance and quality in the renal patients is mischievous because of the disability of the kidneys to filter the sodium ions and other excess fluids, so the existing of any disorder in renal function occurs unbalance in sodium levels [10,11]. The aim of the present work is to investigate the effect of Anti Diuretic Hormone (ADH) on kidney functions (Urea, Creatinine, Albumin), Hemoglobin, Electrolyte (sodium, potassium, chloride) on End Stage Renal Failure Disease (ESRD) in pre hemodialysis

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