Study of the analgesic activity of new partially hydrogenated pyridines, α-cyanothioacetamide derivatives in the pharmacological tail heat immersion test on white rats

Abstract

Experimental study of pain helps to understand its mechanisms, features and physiological manifestations, which is essential for physiology, practical biomedicine and pharmacology.
 The new derivatives of di- and tetrahydropyridines synthesized in the research laboratory "Chemex" on the basis of Lugansk State University named after Vladimir Dahl were subjected to virtual bioscreening using the Swiss Target Prediction software package. Biological screening conducted in vivo, in a thermal tail immersion test on white rats, for new, partially hydrogenated pyridines, derivatives of -cyanothioacetamide, showed the presence of the most pronounced analgesic activity (with intra-gastric using at a dose of 5 mg / kg of body weight of a laboratory animal) in four compounds with laboratory ciphers cv-091, cv-095, cv-099, cv-142.