Abstract
Rheological parameters are an important characteristic of semisolid dosage forms. Structural and mechanical characteristics have a noticeable effect on the processes of release and absorption of drugs from ointments, as well as on their consumer properties: spreadability, adhesion, the ability to squeeze out of the tubes.
 The aim: to study the rheological parameters of aqueous solutions of sodium alginate in various concentrations to create medicinal hydrogel compositions.
 Materials and methods: sodium alginate (Shandong Topsea Seaweed Industrial Co., Ltd., China) was used as a gelling agent. The physicochemical properties of the samples were studied according to generally accepted methods of the State Pharmacopoeia of Ukraine. Rheological studies of experimental samples were carried out using a rotational viscometer «Rheolab QC», by Anton Paar (Austria) with coaxial cylinders C-CC27/SS at a temperature 20–25 °С.
 Results and discussion: the rheological profiles of sodium alginate gels have a non-Newtonian type of flow, which makes it possible to characterize them as systems with plastic-viscous properties. Gels with a sodium alginate concentration of 1.5–2 % have the best indicators of yield stress, hysteresis loop area, mechanical stability and dynamic flow coefficients. This indicates a low degree of destruction of the structural grid in the process of mechanical action and the presence of thixotropic bonds.
 Conclusions: sodium alginate gel base at 0.5 % and 1 % concentration is less stable under stress compared to sodium alginate bases at 1.5 % and 2 % concentration. The gel base of sodium alginate at a concentration of 2 % has the optimal mechanical stability value.
Highlights
In an integrated approach to the problem of local treatment of wounds and burns, one of the main places is given to treatment using semisolid pharmaceutical forms
In the course of the experiment, the structural and mechanical characteristics of sodium alginate gels prepared in various concentrations and their effect on the rheological and organoleptic properties of gels were investigated
The results obtained have shown that, in terms of its structural and mechanical parameters, the gel base of sodium alginate is acceptable for the creation of semisolid dosage forms for topical use
Summary
In an integrated approach to the problem of local treatment of wounds and burns, one of the main places is given to treatment using semisolid pharmaceutical forms (gels, creams). The course of the wound process is a complex set of protective reactions of the body, the development of which occurs as a response to tissue damage. The body’s defense reactions are manifested in the form of destructive and regenerative processes in the wound area and general reactive changes of the body. There are many features, pathways for the course of the wound process and wound healing. It is necessary to take into account the peculiarities of the course of a particular wound process. This should be taken into account when developing a technology for obtaining wound dressings (applications) used in various fields of medicine
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