Abstract
Aim. The development of the composition of the dental gel for the treatment of infectious and inflammatory diseases of the oral cavity, taking into account the physicochemical properties of the active pharmaceutical ingredients, namely the justification of the type and concentration of the gelling agent and other excipients.Methods. The determination of organoleptic characteristics, uniformity of gel samples, pH of aqueous extract, and structural viscosity index was carried out according to the methods of the State Pharmacopoeia of Ukraine. Rheological studies were carried out using a rotational viscometer of the rotating type BROOKFIELD DV-II + PRO (USA) with a coaxial cylinder system.Results. In order to choose the optimal composition of the gel base, experimental samples with various gelling agents were developed (Carbopol 974P, Carbopol 934P, Carbopol Ultrez 10, xanthan gum, sodium alginate, sodium carmellose) and their organoleptic characteristics, structural viscosity and colloidal stability were studied. The physicochemical and rheological studies that were carried out, allowed us to conclude that it is rational to use the Carbopol Ultrez 10 gel former at a concentration of 1.1 %. When choosing neutralizing agents, sodium hydroxide and trometamol were used in the studies. According to the results of studies, sodium hydroxide at a concentration of 0.32 % was selected as a neutralizer, which provides maximum, stable viscosity in the pH range from 5.0 to 7.0.Concusions. The composition of the basis of a dental gel for the treatment of infectious and inflammatory diseases of the oral cavity has been developed: Carbopol Ultrez 10 - 1.1 %, sodium hydroxide solution 10 %–0.32 %
Highlights
Oral disease and mucosal lesions are among the most common medical problems [1]
According to our previous studies, it was found that the selected active substances are well soluble in water or hydrophilic solvents, but the solubility of individual active pharmaceutical ingredient (API) is strongly influenced by the temperature factor [24]
It was rational for the preparation of dental gel to use hydrophilic gel formers
Summary
Oral disease and mucosal lesions are among the most common medical problems [1]. Taking into account the above information, during the design of a complex drug it is necessary to choose an active pharmaceutical ingredient (API) that will exhibit, first of all, antibacterial action. That is why we have chosen metronidazole and miramistin to provide a broad spectrum of antibacterial effect as active substances for the developed product. The choice of dosage form is essential to ensure the effectiveness of pharmacotherapy of various diseases, in particular, are well recommended in the provision of dental care the use of prolonged dosage forms of application in the form of gels [6]. When creating a gel formulation, a whole set of excipients is used, which ensures the physical, chemical and microbiological stability of the product over a period. It is very important to use adjuvants optimally, as their share is constantly increasing today
Sign-in/Register to view highlights & summary Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callDisclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
