Study of streptococcus pneumonia capsular polysaccharide antibodies in patients with chronic obstructive pulmonary disease

Abstract

Objective To study streptococcus pneumonia capsular polysaccharide antibodies of patients with chronic obstructive pulmonary disease (COPD) in acute exacerbation and the feasibility of vaccination for patients with COPD.Methods The COPD in acute exacerbation without respiratory failure (RF) (COPD without RF group),COPD in acute exacerbation with RF (COPD with RF group),asthma (asthma group),healthy elderly examination (elderly examination group) and healthy youth examination (youth examination group) were selected,and each group had 15 cases.The levels of streptococcus pneumonia capsular polysaccharide antibodies IgG,IgM and IgA were measured in all groups.Results There was no significant difference in IgG among the five groups (P ＞ 0.05 ).The levels of IgM in COPD without RF group and elderly examination group were significantly lower than those in COPD with RF group,asthma group and youth examination group (0.554 ± 0.309 and 0.538 ± 0.327 vs.0.810 ± 0.387,0.887 ± 0.278 and 0.852 ± 0.305,P ＜ 0.05 ).Although the level of IgA in COPD without RF group was significantly lower than that in youth examination group (0.532 ±0.297 vs.0.930 ±0.502,P ＜0.05),there was no significant difference among the five groups.Conclusion Patients with COPD should inoculate pneumococcal vaccination. Key words: Pulmonary disease, chronic obstructive; Bacterial capsules; Pneumococcal infections; Vaccines ; Antibodies