Study of Stability of Sulfadiazine Sodium Injection I : Determination of Solubility of Sulfadiazine Sodium as a Function of pH in Several Parenteral Solvent Systems

Abstract

An investigation was conducted to stabilize sulfadiazine sodium injection when exposed to various storage conditions. Prolonged storage of sulfadiazine sodium injection U. S. P. has been known to result in coloration due to oxidation and formation of a precipitate. This study deals with the relationship of sulfadiazine sodium solubility with the hydrogen ion concentration in several solvent systems which have been employed in injectable products. Solubility curves were determined for a number of solvents and from these results their usefulness was ascertained.