Study of spontaneous rosette formation and changes of sialic acid content in the surface glycoproteins of macrophages induced by hamster transplantable melanomas

Abstract

The influence of two kinds of transplantable melanomas on the content of sialic acids in the surface glycoproteins of hamster peritoneal macrophages was studied, and the ability of these cells to form spontaneous rosettes. It has been found that the intensification of rosette formation by macrophages with SRBC depends on the melanoma line. No correlation has, however, been found between changes in the sialic acids content and the ability of macrophages to form rosettes under the influence of melanomas differing in malignancy.