Abstract
Background: Sperm DNA fragmentation test is an advanced test for proper sperm function with respectto semen analysis, as semen analysis is used for motility and morphology assessment, it cannot explainsperm at molecular level and thus SDF test has been introduced to evaluate male fertility. The integrity ofgenetic material in sperm is crucial for successful fertilization & normal embryo development as this willlead to proper transmission of genetic information. Patients having varicocele, recurrent failure of ARTtecniques and improper lifestyle (radiation, smoking, alcohol, BMI, ageing, etc) are considered for spermDNA fragmentation test. SDF test is useful in selecting patients for the ART procedures i.e. IVF/ICSI/IUIand highest pregnancy and live birth outcomes.Objectives:· To predict male infertility with normal semen parameters & its diagnostic values.· To investigate the clinical factors related to sperm DNA fragmentation in male with infertility.· To investigate the rate of sperm DNA fragmentation in male related to improper fertilization, embryodevelopment and recurrent pregnancy loss.Methods: The participants (n=40) with male fertility problems will be included in randomised control trial.All 40 participants will be randomly selected to evaluate their sperm DNA integrity from their respectivesemen samples using sperm chromatin dispersion test.Discussion: Efficiency of the Sperm DNA Fragmentation test is assessed by performing sperm chromatindispersion test on respective processed semen sample using Halosperm G2 test kit.
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