Abstract
Psoriasis is a chronic multi-systemic inflammatory disease that affects the epidermal barrier. Emollients can be used as a coadjutant therapy for psoriasis management, but little is known about how the epidermal barrier function in psoriatic patients is modified by moisturizers. The objective of this study is to evaluate the effect of Vaseline jelly and a water-based formula on epidermal barrier function in psoriatic patients. Thirty-one patients with plaque-type psoriasis and thirty-one gender and age-matched healthy controls were enrolled in the study. Temperature, transepidermal water loss (TEWL), stratum corneum hydration (SCH), pH, elasticity and the erythema index were measured using non-invasive tools before and after applying Vaseline jelly and a water-based formula. TEWL was higher in psoriatic plaques than uninvolved psoriatic skin (13.23 vs. 8.54 g·m−2·h−1; p < 0.001). SCH was lower in psoriatic plaques than uninvolved psoriatic skin and healthy skin (13.44 vs. 30.55 vs. 30.90 arbitrary units (AU), p < 0.001). In psoriatic plaques, TEWL decreased by 5.59 g·m−2·h−1 (p = 0.001) after applying Vaseline Jelly, while it increased by 3.60 g·m−2·h−1 (p = 0.006) after applying the water-based formula. SCH increased by 9.44 AU after applying the water-based formula (p = 0.003). The use of emollients may improve epidermal barrier function in psoriatic patients. TEWL is decreased by using Vaseline, and SCH is increased by using the water-based formula.
Highlights
Psoriasis is a chronic, immune-mediated inflammatory disease that affects 1–3% of the world’s population [1]
The objective of this study is to evaluate the impact of emollients on epidermal barrier function in patients with psoriasis
The body mass index (BMI) was higher in the psoriasis group (30.88 vs. 24.01 kg/m2, p < 0.001), and the abdominal perimeter was higher in psoriatic patients
Summary
Immune-mediated inflammatory disease that affects 1–3% of the world’s population [1]. Prevalence rates show worldwide geographic variation from. The most common manifestations of psoriasis are scattered, erythematous, scaly papules and plaques. This condition presents different skin patterns, and may even affect several joints and cause changes in the nails. Even though numerous risk factors have been related to its predisposition or pathology, such as epigenetic alterations, obesity, alcohol consumption, smoking and stress [3,4]. Psoriasis causes great psychosocial impact [5] and is related to many organic comorbidities, such as cardiovascular disease [6]
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