Study of Serum Uric Acid in Cerebrovascular Disease

Abstract

A case control study was carried out in the Department of Biochemistry, BSMMU from January to December 2007 to evaluate the association of uric acid with cerebrovascular disease (CVD) in a Bangladeshi population. A total number of 135 subjects of both sexes were grouped as group-I (CVD cases) and group-II (Healthy controls). Group-I include 85 cases, 59 were ischaemic cerebrovascular disease (ICVD) and 26 were haemorrhagic cerebrovascular disease (HCVD). By taking the history and doing the clinical examination and laboratory investigations diabetes mellitus, malignant disease, renal disease, thyroid disorder, liver disease & diuretic medication were excluded from study subjects. Serum uric acid was measured in all study subjects. The mean serum uric acid concentration of CVD, ICVD, HCVD cases and control subjects were 5.98±1.52 mg/dl, 6.04±1.45 mg/dl, 5.85±1.68 mg/dl & 5.00±1.35 mg/dl respectively. Serum uric acid found significantly increased in CVD, ICVD and HCVD cases in comparison to control subjects. No difference was found in serum uric acid in between ICVD and HCVD cases. Key words: Uric acid; cerebrovascular disease; ischemic cerebrovascular disease; haemorrhagic cerebrovascular disease. DOI: 10.3329/jdmc.v18i1.6299 J Dhaka Med Coll. 2009; 18(1) : 15-19