STUDY OF SERUM URIC ACID, CALCIUM AND ALPAND URINARY HYDROXYPROLINE CREATININE RATIO IN POSTMENOPAUSAL WOMEN

Abstract

During menopause women succumb to physiological and biochemical changes along with middle age health hazards. In view of sudden fall in Estrogens during menopause Osteoporosis of aging is fortied by Estrogen deciency. The present study was done to evaluate bone health through biochemical parameters in Guntur Urban area between September 2021 and January 2022. 50 Premenopausal women and 60 postmenopausal women were selected for the study after screening verbally . Serum Calcium, Phosphorus, Alk, Phosphatase and Uric acid along with 24Hrs urinary excretion of Creatinine, Calcium and Hydroxyproline were estimated in both groups. We could not nd wide difference in the mean values of serum Ca , P, ALP& UAbut Urine 24 Hrs Ca was lower in postmenopausal women (104.55±23.86) compared to premenopausal group (124.42 ±17.78 ). Urine Hydroxyproline(HOP) showed higher values in postmenopausal women (25.79±1.44 ) than in Premenopausal women.(18.00 ± 2.55). All the analytes showed statistically signicant values between the groups and within the groups with P value value of <0.0001. 24Hrs urine Hydroxyproline , which is collagen degradation product correlated with 24hrs urine Ca and Creatinine.With P value < 0.0001 Serum ALP , Ca & Uric acid as shown by ANOVA, both within groups and between groups was statistically signicant P <0.0001. We conclude that collagen degradation product like HOPcan be evaluated and considered as marker for assessment of bone health in postmenopausal women.