Abstract
BackgroundRenal dysfunction, increased xanthine oxidase activity and oxidative stress in placenta contributes to the elevated uric acid levels in preeclampsia (PE).ObjectiveTo determine serum uric acid and creatinine in hypertensive disorders of pregnancy and correlate with fetal outcome.Materials and MethodsPregnant women ≥32 weeks of gestation. Study population included 3 groups, 31 normotensive pregnant (NP) women as controls, 30 pregnant women with gestational hypertension (GH) and 30 with PE.ResultSerum uric acid and creatinine levels were significantly elevated in PE (6.26±1.19 and 0.94±0.26 mg/dL) when compared with Pregnancy induced hypertension (PIH) (4.27± 1.0 and 0.66 ±0.19 mg/dL) and NP (4.25 ± 0.8 and 0.63± 0.13 mg/dL) (P-value <0.001 and <0.001) respectively. Receiver operation characteristics curves demonstrated greater sensitivity and specificity for uric acid (86.7% and 83.9%, respectively) in PE than for creatinine (80% and 77.4%, respectively). Uric acid had strong and negative correlation with fetal birth weight in PE (r = −0.59, P = 0.006), where as creatinine had negative but weak correlation (r= −0.03, P=0.87).ConclusionSerum uric acid is a better diagnostic and predictive marker for PE and fetal outcome respectively.
Highlights
Hypertensive disorders complicating pregnancy are the most common and serious medical disorder and constitute up to 2–10% of all pregnancies.[1]
Gestational hypertension (GH), preeclampsia (PE), and eclampsia are a part of a spectrum of hypertensive disorders that complicate pregnancy as specified by the National High Blood Pressure Education Program (NHBPEP) working group.[2]
The mean serum uric acid and creatinine levels were significantly elevated in PE (6.26 ± 1.19 mg/dL; 0.94 ± 0.26 mg/dL) when compared with gestational hypertension (GH) (4.27 ± 1.0 mg/dL; 0.66± 0.19 mg/dL) and normotensive pregnant (NP) (4.25 ± 0.8 mg/dL; 0.63 ± 0.13 mg/dL), respectively
Summary
Hypertensive disorders complicating pregnancy are the most common and serious medical disorder and constitute up to 2–10% of all pregnancies.[1]. Serum uric acid and creatinine levels are a part of work up for the pregnant women with hypertension. The elevated levels of these parameters were due to decreased urinary clearance secondary to reduced GFR and increased reabsorption.[3] Serum uric acid is a marker of severity of disease and contributes to the pathology of disorder.[4]. Renal dysfunction, increased xanthine oxidase activity and oxidative stress in placenta contributes to the elevated uric acid levels in preeclampsia (PE). Objective—To determine serum uric acid and creatinine in hypertensive disorders of pregnancy and correlate with fetal outcome. Result—Serum uric acid and creatinine levels were significantly elevated in PE (6.26±1.19 and 0.94±0.26 mg/dL) when compared with Pregnancy induced hypertension (PIH) (4.27± 1.0 and 0.66 ±0.19 mg/dL) and NP (4.25 ± 0.8 and 0.63± 0.13 mg/dL) (P-value
Sign-in/Register to view highlights & summary Sign-in/Register to access full text options 
Talk to us
Join us for a 30 min session where you can share your feedback and ask us any queries you have
Schedule a callMore From: International Journal of Medical Science and Public Health
Disclaimer: All third-party content on this website/platform is and will remain the property of their respective owners and is provided on "as is" basis without any warranties, express or implied. Use of third-party content does not indicate any affiliation, sponsorship with or endorsement by them. Any references to third-party content is to identify the corresponding services and shall be considered fair use under The CopyrightLaw.
