STUDY OF SERUM PROSTATE SPECIFIC ANTIGEN (PSA) LEVELS AS A DIAGNOSTI

Abstract

Background: PCOS is a reproductive endocrine disorder marked by oligo-ovulation/chronic anovulation, menstrual abnormalities, hyperandrogenism, and obesity. In females with PCOS, PSA has been identied as a potential new marker.. PSA may be a useful clinical marker and maybe a novel diagnostic criterion for hyperandrogenemia in females, despite the fact that its signicance in PCOS patients is undetermined. Objectives: To evaluate and establish the role of PSA in association with elevated levels of androgens and altered LH/FSH ratio as a biochemical marker in aiding the diagnosis of PCOS. Methods:Atotal of 100 patients divided into 2 groups of 50 each, In Group A50 patients diagnosed with PCOS and in Group B 50 Healthy patients without PCOS were analyzed for serum PSA, testosterone, prolactin, TSH, FSH and LH levels. Results: In the PCOS group, there was a slightly negative correlation with age, positive correlation between serum total testosterone and PCOS, and a moderately positive correlation with Ferriman - Gallwey score (FGS) for hirsutism. Conclusion: In females with PCOS, serum PSA levels increased signicantly and were positively correlated with total testosterone and FGS score, while being negatively correlated with age. As a result, serum PSA levels in females with Polycystic ovarian syndrome can be used as a diagnostic and biochemical marker for PCOS and other hyperandrogenic disorders.