STUDY OF SERUM IRISIN AND ITS ASSOCIATION WITH INSULIN RESISTANCE IN POLY CYSTIC OVARY SYNDROME

Abstract

OBJECTIVE: Poly cystic ovary syndrome (PCOS) is clinically heterogeneous endocrine disorders. Insulin resistance-related proteins play a role in the etiopathogenesis of PCOS. Irisin is a newly identied myokine which act like adipokines. Irisin has been shown to be associated with insulin-resistance and metabolic syndrome. The purpose of this study was to determine the serum levels of irisin in PCOS patients and evaluate its association with insulin resistance. PATIENTS AND METHODS: Eighty ve PCOS patients and eighty ve matched healthy controls were enrolled to study .Serum irisin levels , anthropometric and metabolic parameters including HOMA-IR were measured. Linear regression analysis was employed to study the relationship between irisin and metabolic parameters. RESULTS: Serum irisin level in PCOS patients ( mean value ; 0.50+0.07 ng/ml) was signicantly elevated when compared to control group ( mean value; 0.203+0.043ng/ml)(p value <0.001).Linear regression analysis showed that serum irisin was positively associated with body mass index , fasting insulin and lipid prole in PCOS patients. CONCLUSIONS: Serum irisin level of PCOS patients was high compared to that of healthy control subjects . In patients with PCOS , this situation may be due to insulin resistance .