Study of serum ghrelin and resistin levels and their correlation with zinc and magnesium in men with type 2 diabetes

Abstract

Introduction: The objectives of our work were to compare the serum concentrations of lipid parameters,insulin, resistin, ghrelin, zinc and magnesium between two groups of men with obese type 2 diabetes and a control group and to study possible correlations between these differentparameters. Material and methods: This was a monocentric case-control study during the period 19 October 2015 to 18 November 2015. It included biological parameters from two separate samples: a group of 41 male, obese, type 2 diabetic patients and a group of 34 diabetes-free controls. Results: Mean plasma ghrelin concentrations were significantly lower in patients with type 2 diabetes compared to those in the control group: (14.05 ± 2.35 pg/mL) versus (45.45 ± 13.59 pg/mL). Mean resistance was significantly higher in diabetics (10.09 ± 2.63 ng/mL) compared to healthy subjects (2.22 ± 0.58 ng/mL). In multivariate analysis, body mass index (BMI) and insulin levels were factors that could influence zincemia variability, while BMI and ghrelinaemia appeared to be predictors of magnesium variability. Discussion: Most correlation studies are based on serum zinc concentration. The different possible correlations between resistin, zinc, magnesium and ghrelin require an increase in the size of the study population, as well as an increase in nutritional surveys during the different stages of type 2 diabetes and obesity. Conclusion: It would be interesting to evaluate, according to the stages of obesity, serum levels of magnesium and ghrelin, on the one hand, and serum levels of zinc and insulin, on the other hand.