Abstract
Serum gamma glutamyl transferase (GGT or γ-GT) is a microsomal enzyme, catalyzes the transfer of the gamma-glutamyl moiety of glutathione to various peptide acceptors. It is a reliable diagnostic marker of alcohol ingestion which is one of the most sensitive and most commonly employed biochemical marker of alcohol consumption . This study was carried out with 30 alcoholic hepatitis and 30 normal non-alcoholic control subjects. The aim of this study was to establish the role of serum GGT alone in the diagnosis of alcoholic hepatitis. A significant correlation in the level of serum GGT is observed in alcoholics when compared with the normal subjects. The enzyme activity of GGT in serum is increased in average by 527.31% in the patients with alcoholic hepatitis compared to normal control subjects (p<0.05). Measurement of GGT in serum appears to be a sensitive index with low specificity in the diagnosis of alcoholics with hepatitis when correlated clinically.
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