Study of serum ferritin levels as an inflammatory marker and its relationship with Hba1c in type 2 diabetes mellitus

Abstract

Type 2 diabetes mellitus is the leading metabolic disorder globally as well as in India, affecting more than 135 million people all over the world.1 Studies have shown a strong association between elevated serum levels of ferritin and type 2 DM.4 Serum ferritin could be an independent determinant of poor metabolic control in the diabetic patient.2 Serum ferritin as an inflammatory marker in type 2 diabetes mellitus is an underutilized but can be a reliable tool to evaluate the metabolic disorder.4 We assessed 180 subjects (120 cases and 60 controls) in the current study. The case group was divided in to 2 groups based on the HbA1c levels as Group B: HbA1C < 6g> 6g/dl (60 cases). The work embodied in the study includes subjects diagnosed of type 2 diabetes mellitus above 40 years of age, attending diabetic OPD in ESIC PGIMSR, of both gender. Group A (control) includes healthy adults above 30 years of age both the sexes. Serum levels Fasting sugar and Ferritin were estimated along with Glycated hemoglobin levels. Mean serum ferritin levels in Group A, Group B and Group C were 112.08 ± 90.1ng/dl, 334.4 ± 39.1ng/mL and 368.9 ± 46.7 ng/ respectively. Serum ferritin levels in Group B and C were significantly higher than Group A (p Keywords: Type 2 diabetes, Serum ferritin, Glycated hemoglobin, Inflammatory marker.